But that’s far easier said than done. With all the injuries last week and the uncertainty over how the new season will play out, fantasy managers have some tough calls to make in Week 2. That’s why we’re here to help.

These fantasy football rankings are based on the point-per-reception (PPR) scoring used in most seasonal and daily fantasy football formats. One point is awarded for every 10 rushing and receiving yards and one point for every 20 passing yards. Six points are awarded for touchdowns scored, four points for passing TDs and one point for receptions.

Rankings are compiled by Daniel Dobish, TheHuddle.com. 

(*-check status before kickoff)

• Josh Allen injured his left hand in Week 1 diving for a touchdown, but has been cleared to practice and should be fine to start on Thursday night.
• Justin Fields is expected to get another start for Pittsburgh with Russell Wilson still dealing with a calf injury.

Fantasy football Week 2 running back rankings

• De’Von Achane (ankle) is questionable and Raheem Mostert (chest) is out for Thursday night vs. Buffalo. Look for Jeff Wilson Jr. to see more reps with Jaylen Wright set to make his NFL debut due to the short week.
• Christian McCaffrey (calf, Achilles) appears likely to miss a second consecutive game. The Niners can feel more comfortable giving him extra time to recover after Jordan Mason‘s big game (152 rushing yards, TD) on Monday night.